منابع مشابه
Development of chemical and chemo-enzymatic glycosylations
Glycosidic compounds are indispensable molecules in living systems. Biological phenomena such as cell wall formation, energy storage, and cell recognition strongly depend on the multi-functional characters of these substances. Development of highly regio- and stereoselective glycosylation reactions is necessary to provide sufficient amounts of specific compounds in basic research as well as for...
متن کاملProtecting groups in carbohydrate chemistry: influence on stereoselectivity of glycosylations.
Saccharides are polyhydroxy compounds, and their synthesis requires complex protecting group manipulations. Protecting groups are usually used to temporarily mask a functional group which may interfere with a certain reaction, but protecting groups in carbohydrate chemistry do more than protecting groups usually do. Particularly, protecting groups can participate in reactions directly or indire...
متن کاملDetecting Glycosylations in Complex Samples
Glycoproteins are the highly diverse key element in the process of cell – cell recognition and host – pathogen interaction. It is this diversity that makes it a challenge to identify the glyco-peptides together with their modification from trypsin-digested complex samples in mass spectrometry studies. The biological approach is to isolate the peptides and separate them from their glycosylation ...
متن کاملChemical O‐Glycosylations: An Overview
The development of glycobiology relies on the sources of particular oligosaccharides in their purest forms. As the isolation of the oligosaccharide structures from natural sources is not a reliable option for providing samples with homogeneity, chemical means become pertinent. The growing demand for diverse oligosaccharide structures has prompted the advancement of chemical strategies to stitch...
متن کاملStereoselective glycosylations using oxathiane spiroketal glycosyl donors.
Novel oxathiane spiroketal donors have been synthesised and activated via an umpolung S-arylation strategy using 1,3,5-trimethoxybenzene and 1,3-dimethoxybenzene. The comparative reactivity of the resulting 2,4,6-trimethoxyphenyl (TMP)- and 2,4-dimethoxyphenyl (DMP)-oxathiane spiroketal sulfonium ions is discussed, and their α-stereoselectivity in glycosylation reactions is compared to the anal...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: OMICS: A Journal of Integrative Biology
سال: 2010
ISSN: 1536-2310,1557-8100
DOI: 10.1089/omi.2010.0035